Related Experiment Videos
Expression of the lung resistance protein (LRP) in primary breast cancer
G Pohl1, M Filipits, R W Suchomel
1Department of Internal Medicine I, University of Vienna, Austria.
Background:
To determine the clinical significance of the lung resistance protein (LRP) in breast cancer, we have studied its expression in primary breast carcinomas (n = 99) and assessed the association of this expression with clinical parameters of the patients.
Materials And Methods:
LRP expression was immunohistochemically determined by means of the monoclonal antibody LRP-56 on frozen tumor sections.
Results:
LRP expression was negative in 12%, low in 20%, intermediate in 47% and high in 21% of the carcinomas. LRP expression was independent of age of the patients, histology, tumor grade, estrogen receptor as well as progesterone receptor status, tumor size and lymph node involvement. Kaplan-Meier analyses revealed that both overall survival and disease-free survival were independent of the degree of LRP expression.
Conclusions:
LRP is frequently expressed in breast carcinomas, but is neither associated with known prognostic factors, nor a prognostic factor by itself.