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Related Experiment Videos

Morphology of the designed biodegradable cisplatin microsphere.

S Natsugoe1, K Tokuda, M Shimada

  • 1First Department of Surgery, Kagoshima University School of Medicine, Japan.

Anticancer Research
|March 4, 2000
PubMed
Summary

This study shows cisplatin-poly(lactic-co-glycolic acid) microspheres (CDDP-PPMS) effectively release cisplatin over four weeks. CDDP-PPMS demonstrated histological efficacy against peritoneal metastasis in omentum tissue.

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Annals of oncology : official journal of the European Society for Medical Oncology·2012

Area of Science:

  • Biomaterials Science
  • Oncology
  • Drug Delivery Systems

Background:

  • Polymeric microspheres are investigated for controlled drug release in cancer therapy.
  • Cisplatin (CDDP) is a widely used chemotherapeutic agent with limitations in delivery and efficacy.
  • Poly-d,l-lactic acid (PLA) and polyethylene glycol acid (PEG) are biocompatible polymers used in drug delivery.

Purpose of the Study:

  • To evaluate the morphological changes and in vitro release characteristics of cisplatin-loaded poly-d,l-lactic acid and polyethylene glycol acid microspheres (CDDP-PPMS).
  • To assess the in vivo behavior and histological efficacy of CDDP-PPMS after intraperitoneal administration in a peritoneal metastasis model.

Main Methods:

  • Microsphere preparation involving embedding cisplatin (CDDP) within poly-d,l-lactic acid (PLA) and polyethylene glycol acid (PEG) polymer matrix.

Related Experiment Videos

  • In vitro drug release studies to determine the release profile of CDDP from CDDP-PPMS over an extended period.
  • Scanning electron microscopy (SEM) to analyze the surface morphology of CDDP-PPMS before and after incubation.
  • Intraperitoneal administration of CDDP-PPMS in a Yoshida sarcoma peritoneal metastasis model, followed by histological examination of omentum tissue.

    • Main Results:

    • In vitro release of CDDP from CDDP-PPMS was sustained for over four weeks.
    • SEM revealed spherical, smooth microspheres initially, with pore formation observed after six months.
    • CDDP-PPMS particles were localized within the stomata of the omentum post-administration.
    • Histological analysis showed CDDP-PPMS presence within necrotic tissues of the omentum, indicating localized drug delivery and efficacy against peritoneal metastasis.

    Conclusions:

    • CDDP-PPMS exhibits sustained in vitro release of cisplatin.
    • The microspheres demonstrate favorable in vivo distribution and histological efficacy in targeting peritoneal metastasis within the omentum.
    • These findings support the potential of CDDP-PPMS as a localized drug delivery system for peritoneal carcinomatosis.