Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Oncogenes.

R Todd1, D T Wong

  • 1Oral and Maxillofacial Surgery, Massachusetts General Hospital, Harvard School of Dental Medicine, Boston 02114, USA. randy-todd@hms.harvard.edu

Anticancer Research
|March 4, 2000
PubMed
Summary
This summary is machine-generated.

Oncogenes, mutated proto-oncogenes, drive human cancer by altering cell growth and survival. Understanding these genetic changes is crucial for developing targeted cancer therapies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Performance of ChatGPT in French language analysis of multimodal retinal cases.

Journal francais d'ophtalmologie·2024
Same author

Development of the high energy engineering X-ray (HEX) superconducting wiggler, magnetic measurement, installation, and commissioning.

The Review of scientific instruments·2023
Same author

Effect of high-flow nasal oxygen on hypoxaemia during procedural sedation: a systematic review and meta-analysis.

Anaesthesia·2022
Same author

Evidence-based Canadian guidelines for tele-retina screening for diabetic retinopathy: recommendations from the Canadian Retina Research Network (CR2N) Tele-Retina Steering Committee.

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie·2020
Same author

Intravascular leiomyomatosis: A case report and review of the literature.

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology·2014
Same author

Cytological follow-up after hysterectomy: is vaginal vault cytology sampling a clinical governance problem? The University Hospital of North Staffordshire approach.

Cytopathology : official journal of the British Society for Clinical Cytology·2014
Same journal

Corrigendum.

Anticancer research·2026
Same journal

Geographic Variation in Stage at Diagnosis of Skin Cancer in the United States: A National Cancer Database Analysis.

Anticancer research·2026
Same journal

Anti-tumor Effects of Loureirin A Treatment in Colorectal Cancer Cells <i>via</i> Inhibition of AKT Phosphorylation.

Anticancer research·2026
Same journal

Bayesian Analysis to Refine East Asian Subgroup Estimates in the CLEAR Trial (Lenvatinib Plus Pembrolizumab <i>vs</i>. Sunitinib) for Advanced Renal Cell Carcinoma.

Anticancer research·2026
Same journal

Pulsed Electromagnetic Field Increases Doxorubicin-induced Mitotic Slippage in MDA-MB-231 Breast Cancer Cells.

Anticancer research·2026
Same journal

Geographic Disparities in Socioeconomic Factors and Advanced-stage Presentation in Rectosigmoid Cancer: A National Cancer Database Analysis.

Anticancer research·2026
See all related articles

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Oncogenes arise from mutations in proto-oncogenes, which are normal cellular genes.
  • These mutated genes were first identified in viruses causing various animal cancers.
  • Oncogenes are significant factors in human cancer development (carcinogenesis).

Purpose of the Study:

  • To explain the origin and function of oncogenes.
  • To detail how proto-oncogenes are altered to become oncogenes.
  • To describe the role of oncogenes in cancer formation.

Main Methods:

  • Review of existing literature on oncogene discovery and function.
  • Analysis of genetic alterations (point mutation, amplification, rearrangement) in proto-oncogenes.
  • Examination of the impact of oncoproteins on cellular signaling pathways.

Related Experiment Videos

Main Results:

  • Proto-oncogenes can be structurally altered, leading to changes in protein expression or function.
  • Oncoproteins disrupt normal cellular signal transduction pathways.
  • Altered oncogene expression contributes to uncontrolled cell proliferation, cell cycle dysregulation, and blocked apoptosis.

Conclusions:

  • Oncogenes are key drivers of human cancer.
  • The disruption of normal cellular processes by oncoproteins promotes tumor formation.
  • Targeting oncogene pathways offers potential therapeutic strategies.