Therapeutic options in patients with Barrett's esophagus

The rising incidence of esophageal adenocarcinoma has focused attention on the only known risk factor: Barrett's esophagus. Practice guidelines for the diagnosis, surveillance and management of Barrett's esophagus were published recently. Although the ultimate goal in the management of this premalignant condition would be the permanent elimination of Barrett's mucosa, current therapeutic options are limited or still in the investigational stages. This review summarizes current medical and surgical treatment options and introduces endoscopic ablative modalities currently under investigation.