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Studies on muscarinic M2 receptors in smooth muscle
1Department of Pharmaceutical Biology and Pharmacology, Victorian College of Pharmacy, Monash University, Parkville, Australia.
Proceedings of the Western Pharmacology Society
|March 4, 2000
Abstract:
Histamine after M3 receptor alkylation with 4-DAMP mustard does not serve simply as a spasmogen but facilitates visualization of the M2-mediated contraction induced by oxotremorine M. We speculate that M3 receptor activation has a similar role in untreated tissue. The facilitation appears to involve protein kinase C. The results with propranolol suggest that the phospholipase D pathway may also be important in the development of the M2-mediated response.