Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genetics and evolution of parasites and hosts: some comments.

D Walliker1, A P Waters

  • 1Institute of Cell, Animal and Population Biology, University of Edinburgh, UK. d.walliker@ed.ac.uk

Parassitologia
|March 4, 2000
PubMed
Summary

Understanding malaria parasite genetics and host-pathogen interactions is key to analyzing disease outcomes and evolution. This commentary explores genetic factors influencing malaria infection severity and co-evolution.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genomics and epigenetics of sexual commitment in Plasmodium.

International journal for parasitology·2017
Same author

Simple and sensitive antimalarial drug screening in vitro and in vivo using transgenic luciferase expressing Plasmodium berghei parasites.

International journal for parasitology·2008
Same author

Standardizing PCR for molecular epidemiology studies of malaria.

Parasitology today (Personal ed.)·2006
Same author

Ronald ross: malariologist and polymath. A biography.

Parasitology today (Personal ed.)·2006
Same author

Transfection systems for animal models of malaria.

Parasitology today (Personal ed.)·2006
Same author

Erratum.

Parasitology today (Personal ed.)·2006

Area of Science:

  • Genetics and Evolution of Infectious Diseases
  • Parasitology
  • Immunogenetics

Background:

  • Malaria's complex manifestations result from gene interactions between the Plasmodium parasite and its human host.
  • Understanding pathogen and host genetics is crucial for analyzing infectious disease dynamics.

Purpose of the Study:

  • To provide commentary on key aspects of malaria parasite genetics and evolution.
  • To highlight the interplay between parasite and host genes in determining infection outcomes.
  • To discuss the genetic basis of parasite virulence, host resistance, and co-evolutionary dynamics.

Main Methods:

  • Commentary and discussion based on existing knowledge of malaria genetics and evolution.
  • Analysis of genetic factors influencing parasite infectivity and virulence.
  • Exploration of host genetic determinants of resistance and susceptibility.

Main Results:

  • Parasite genes dictate infectivity and virulence, while host genes influence resistance or susceptibility.
  • The outcome of malaria infection (asymptomatic to cerebral malaria) is a product of complex genetic interactions.
  • Population genetics principles (mutation, recombination, gene flow) shape parasite genotypes and drive co-evolution.

Conclusions:

  • A comprehensive understanding of malaria requires integrating parasite and host genetics.
  • Genetic analyses are essential for deciphering parasite evolution and host-pathogen co-evolutionary trajectories.
  • Further research into these genetic interactions will inform strategies for malaria control and prevention.

Related Experiment Videos