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Studies on anti-folate antimalarials in east Africa
F Ortelli1, C A Maxwell, J Curtis
1London School of Hygiene and Tropical Medicine, UK.
Parassitologia
|March 4, 2000
Abstract:
Chlorproguanil-dapsone (CD) appears to be a promising anti-folate combination (Amukoye et al., 1997) to substitute for pyrimethamine-sulfadoxine (PS), which has a long half-life and against which there is resistance in several Plasmodium falciparum populations including the highly endemic lowland area near Muheza, Tanzania (Trigg et al., 1997).