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Mouse pancreatic polypeptide modulates food intake, while not influencing anxiety in mice
1Second Department of Internal Medicine, Kobe University School of Medicine, Japan.
Abstract:
This study was designed to investigate the effects of synthetic mouse pancreatic polypeptide (mPP) on feeding and anxiety in mice. The intracerebroventricular (i.c.v.) injection of mPP (0.003-3 nmol) dose-dependently increased food intake. A significant increase was observed 20 min after i.c.v. injection and continued for 4 h. The intraperitoneal (i.p.) injection of mPP (0.03-30 nmol) dose-dependently decreased food intake. A significant decrease was observed 20 min after i.p. injection and continued for 4 h. In the elevated plus maze test, the i.c.v. injection of mPP (0.003-3 nmol) did not affect anxiety behavior. These results suggest that mPP modulates food intake and the Y4 receptor in the brain may contribute to the regulation of feeding, whereas appearing not to influence anxiety in mice.
Insights
Synthetic mouse pancreatic polypeptide (mPP) affects feeding differently based on administration route. Intracerebroventricular injection increased food intake, while intraperitoneal injection decreased it, suggesting central Y4 receptor involvement in feeding regulation.
Area of Science:
- Neuroscience
- Endocrinology
- Behavioral Science
Background:
- Pancreatic polypeptide (PP) is a hormone involved in various physiological processes.
- The role of synthetic mouse pancreatic polypeptide (mPP) in central feeding regulation and anxiety remains to be fully elucidated.
Purpose of the Study:
- To investigate the effects of synthetic mouse pancreatic polypeptide (mPP) on feeding behavior and anxiety in mice.
- To explore the potential involvement of central Y4 receptors in mPP's actions.
Main Methods:
- Administration of synthetic mPP via intracerebroventricular (i.c.v.) and intraperitoneal (i.p.) injections in mice.
- Assessment of food intake following mPP administration.
- Evaluation of anxiety-like behavior using the elevated plus maze test.
Main Results:
- Intracerebroventricular injection of mPP dose-dependently increased food intake, with effects observed within 20 minutes and lasting for 4 hours.
- Intraperitoneal injection of mPP dose-dependently decreased food intake, with similar onset and duration.
- Intracerebroventricular administration of mPP did not significantly alter anxiety behavior in the elevated plus maze test.
Conclusions:
- Synthetic mouse pancreatic polypeptide differentially modulates food intake depending on the route of administration.
- Central Y4 receptors likely play a role in the regulation of feeding behavior by mPP.
- mPP does not appear to influence anxiety-related behaviors in mice.