Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Stroke prevention in sickle cell disease.

R J Adams1

  • 1Department of Neurology, Medical College of Georgia, Augusta, 30912, USA.

Current Opinion in Hematology
|March 4, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association between multimorbidity and undiagnosed obstructive sleep apnea severity and their impact on quality of life in men over 40 years old.

Global health, epidemiology and genomics·2018
Same author

Differential Impact of Index Stroke on Dementia Risk in African-Americans Compared to Whites.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2018
Same author

Antimicrobial-resistant Enterobacteriaceae recovered from companion animal and livestock environments.

Zoonoses and public health·2018
Same author

Neurocognitive dysfunction and pharmacological intervention using guanfacine in a rhesus macaque model of self-injurious behavior.

Translational psychiatry·2015
Same author

Acquired cervical spinal arachnoid diverticulum in a cat.

The Journal of small animal practice·2014
Same author

Intracranial blood flow velocities in patients with sickle cell disease and β-thalassemia intermedia.

American journal of hematology·2013

Sickle cell disease patients face neurological risks like stroke. While transfusions are standard, research is exploring hydroxyurea for stroke prevention and treatment.

Area of Science:

  • Neurology
  • Hematology
  • Pediatrics

Background:

  • Neurological complications, particularly stroke, are a significant concern in sickle cell disease.
  • Increased life expectancy in sickle cell disease patients highlights the need for managing long-term complications.
  • Recent studies have improved understanding of stroke epidemiology in this population.

Purpose of the Study:

  • To summarize current knowledge on stroke in sickle cell disease.
  • To discuss advancements in stroke prevention and treatment strategies.
  • To highlight the role of magnetic resonance imaging (MRI) in identifying silent brain lesions.

Main Methods:

  • Literature review of recent studies on sickle cell disease and stroke.
  • Analysis of clinical trial data for stroke prevention in children.

Related Experiment Videos

  • Discussion of neuroimaging findings, specifically MRI, in relation to cognitive function.

    • Main Results:

    • Stroke is a recognized complication of sickle cell disease.
    • Effective stroke prevention strategies, including clinical trials for children, have been established.
    • Silent brain lesions are common on MRI and correlate with cognitive impairments.

    Conclusions:

    • Transfusion therapy is the current primary intervention for stroke prevention and treatment in sickle cell disease.
    • Hydroxyurea is an emerging interest for stroke management, but efficacy data are lacking.
    • Further research is needed to establish the role of hydroxyurea in sickle cell disease stroke management.