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Structure-activity relationship studies of chloromethyl ketone derivatives for selective human chymase inhibitors
Y Hayashi1, K Iijima, J Katada
1Department of Medicinal Chemistry, Kyoto Pharmaceutical University, Japan.
Bioorganic & Medicinal Chemistry Letters
|March 4, 2000
Abstract:
Based on the SAR study of a classical chloromethyl ketone derivative, Z-PheCH2Cl 1, a series of compounds were synthesized. Among all the derivatives, compound 21 was found to be a potent human chymase inhibitor with no inhibitory activity against human leukocyte cathepsin G.