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Structure-activity relationships of carboxymethylpullulan-peptide-doxorubicin conjugates--systematic modification of
Bioorganic & Medicinal Chemistry Letters
|March 4, 2000
Abstract:
A series of carboxymethylpullulan (CMPul)-doxorubicin (DXR) conjugates bound by peptide spacers of different compositions and lengths were prepared and evaluated for their in vivo antitumor effects. Systematic study of the peptide spacers indicated that CMPul-DXR conjugates bound via appropriate dipeptide spacers were more potent than DXR.