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Mechanistic studies on type I and type II dehydroquinase with (6R)- and (6S)-6-fluoro-3-dehydroquinic acids
E J Parker1, C González Bello, J R Coggins
1University Chemical Laboratory, Cambridge, UK.
Bioorganic & Medicinal Chemistry Letters
|March 4, 2000
Abstract:
(6R)- and (6S)-6-Fluoro-3-dehydroquinic acids are shown to be substrates for type I and type II dehydroquinases. Their differential reactivity provides insight into details of the reaction mechanism and enables a novel enzyme-substrate imine to be trapped on the type I enzyme.