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Related Experiment Videos

Abnormal angular gyrus asymmetry in schizophrenia.

M Niznikiewicz1, R Donnino, R W McCarley

  • 1Laboratory of Neuroscience, Department of Psychiatry, VA Medical Center, Harvard Medical School, Brockton, MA 02301, USA.

The American Journal of Psychiatry
|March 4, 2000
PubMed
Summary
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Schizophrenia patients exhibit reversed asymmetry in the inferior parietal lobule, specifically the angular gyrus. This brain region is crucial for language and thought, offering insights into schizophrenia

Area of Science:

  • Neuroscience
  • Psychiatry
  • Brain Imaging

Background:

  • The parietal lobe, particularly the inferior parietal lobule, plays a key role in attention, memory, and language.
  • These cognitive functions are often impaired in schizophrenia.
  • The inferior parietal lobule is part of the heteromodal association cortex and the semantic-lexical network.

Purpose of the Study:

  • To investigate volume and asymmetry of parietal lobe gyri in schizophrenia using magnetic resonance imaging (MRI).
  • To specifically examine the inferior parietal lobule and angular gyrus, critical for language and thought.

Main Methods:

  • Acquired MRI scans from 15 male chronic schizophrenic patients and 15 matched controls.
  • Analyzed volume and asymmetry of individual parietal lobe gyri.

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Main Results:

  • Comparison subjects showed leftward asymmetry in the inferior parietal lobule (left 7.0% larger).
  • Schizophrenic subjects displayed reversed asymmetry (left 6.3% smaller).
  • The angular gyrus accounted for this difference, with normal left-greater-than-right asymmetry in controls but not in schizophrenic patients.

Conclusions:

  • Schizophrenia is associated with reversed asymmetry in the inferior parietal lobule, localized to the angular gyrus.
  • This finding enhances understanding of the neural basis of language and thought disorders in schizophrenia.