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Salivary cortisol in panic attacks.

B Bandelow1, D Wedekind, J Pauls

  • 1Department of Psychiatry, The University of Göttingen, Germany. bbandel@gwdg.de

The American Journal of Psychiatry
|March 4, 2000
PubMed
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This study found subtle but significant elevations in cortisol during panic attacks in individuals with panic disorder. Saliva sampling proved effective for measuring these neuroendocrine changes during spontaneous panic episodes.

Area of Science:

  • Neuroendocrinology
  • Psychiatry
  • Stress Physiology

Background:

  • Hypothalamic-pituitary-adrenal (HPA) axis dysfunction is implicated in panic disorder, but findings on cortisol levels are inconsistent.
  • Elevated cortisol is a known indicator of HPA axis activation due to stress.

Purpose of the Study:

  • To investigate salivary cortisol levels during unprovoked panic attacks in patients with panic disorder.
  • To assess the utility of saliva sampling for HPA axis research in panic disorder.

Main Methods:

  • 25 patients with panic disorder provided saliva samples during spontaneous panic attacks.
  • Cortisol levels were measured in samples taken during attacks and compared to samples collected 24 hours post-attack.

Main Results:

Related Experiment Videos

  • A modest but statistically significant increase in salivary cortisol was observed during panic attacks compared to baseline (24 hours later).
  • Cortisol elevations did not correlate with panic attack severity or overall illness severity.

Conclusions:

  • Saliva sampling is a viable method for studying neuroendocrine changes, specifically cortisol, during spontaneous panic attacks.
  • This method facilitates research into HPA axis activity in panic disorder.