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Related Experiment Videos

Low dopamine D(2) receptor binding potential in social phobia.

F R Schneier1, M R Liebowitz, A Abi-Dargham

  • 1Anxiety Disorders Clinic and the Brain Imaging Division, New York State Psychiatric Institute, New York 10032, USA. frs1@columbia.edu

The American Journal of Psychiatry
|March 4, 2000
PubMed
Summary

Patients with social phobia have lower dopamine D(2) receptor binding potential in the striatum compared to healthy individuals. This suggests a potential neurobiological link in social anxiety disorder.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Radiology

Background:

  • Social phobia is a common anxiety disorder.
  • The role of dopamine in social phobia is not fully understood.
  • Dopamine D(2) receptors are implicated in reward and motivation pathways.

Purpose of the Study:

  • To compare dopamine D(2) receptor binding potential in patients with social phobia and healthy controls.
  • To investigate potential neurobiological underpinnings of social phobia.

Main Methods:

  • SPECT imaging was used to measure dopamine D(2) receptor binding potential.
  • The radiotracer [(123)I]iodobenzamide ([(123)I]IBZM) was administered.
  • 10 unmedicated patients with generalized social phobia and 10 healthy controls were studied.

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Main Results:

  • Dopamine D(2) receptor binding potential was significantly lower in patients with social phobia.
  • No significant correlation was found between binding potential and social anxiety severity (Liebowitz Social Anxiety Scale).

Conclusions:

  • Generalized social phobia may be associated with reduced dopamine D(2) receptor availability in the striatum.
  • These findings suggest a potential neurochemical alteration in social phobia.