Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nociception01:44

Nociception

Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain. Thus, pain helps the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Resistant and refractory migraine - two different entities with different comorbidities? Results from the REFINE study.

The journal of headache and pain·2024
Same author

Migraine or any headaches and white matter hyperintensities and their progression in women and men.

The journal of headache and pain·2024
Same author

[Migraine in the real-life clinical practice: results of the observational study of diagnosis and treatment patterns in the urban population of the Russian Federation].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2022
Same author

Migraine patients in Germany - need for medical recognition and new preventive treatments: results from the PANORAMA survey.

The journal of headache and pain·2021
Same author

Abdominal incision defect following AAA-surgery (AIDA): 2-year results of prophylactic onlay-mesh augmentation in a multicentre, double-blind, randomised controlled trial.

Updates in surgery·2021
Same author

Headache service quality evaluation: implementation of quality indicators in primary care in Europe.

The journal of headache and pain·2021
Same journal

When the algorithm disagrees: managing AI-generated 'second opinions' in clinical neurophysiology.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2026
Same journal

Cervical nerve root contribution to diaphragm motor innervation revisited via intraoperative clinical and neurophysiological observations.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2026
Same journal

Lower cranial nerve responses after laryngeal stimulation in posterior fossa surgery: a study of medullary complex motor functions.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2026
Same journal

Standardisation matters: the IFCN neuromuscular ultrasound training program.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2026
Same journal

The prospects and challenges of closed-loop high-bandwidth brain-to-body-and-machine interfacing.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2026
Same journal

EEG patterns and cognitive outcomes in chronic respiratory disorders: a systematic review.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2026
See all related articles

Related Experiment Video

Updated: Jun 2, 2026

Whisker-signaled Eyeblink Classical Conditioning in Head-fixed Mice
10:14

Whisker-signaled Eyeblink Classical Conditioning in Head-fixed Mice

Published on: March 30, 2016

A new method to increase nociception specificity of the human blink reflex.

H Kaube1, Z Katsarava, T Käufer

  • 1Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK. holgerk@ion.ucl.ac.uk

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
|March 4, 2000
PubMed
Summary
This summary is machine-generated.

A new surface electrode effectively isolates nociception-specific R2 responses in the blink reflex. This method preferentially targets superficial A-delta fibers, offering a less traumatic approach to studying trigeminal nociception.

More Related Videos

Objective Nociceptive Assessment in Ventilated ICU Patients: A Feasibility Study Using Pupillometry and the Nociceptive Flexion Reflex
06:04

Objective Nociceptive Assessment in Ventilated ICU Patients: A Feasibility Study Using Pupillometry and the Nociceptive Flexion Reflex

Published on: July 4, 2018

Classical Short-Delay Eyeblink Conditioning in One-Year-Old Children
07:36

Classical Short-Delay Eyeblink Conditioning in One-Year-Old Children

Published on: September 1, 2018

Related Experiment Videos

Last Updated: Jun 2, 2026

Whisker-signaled Eyeblink Classical Conditioning in Head-fixed Mice
10:14

Whisker-signaled Eyeblink Classical Conditioning in Head-fixed Mice

Published on: March 30, 2016

Objective Nociceptive Assessment in Ventilated ICU Patients: A Feasibility Study Using Pupillometry and the Nociceptive Flexion Reflex
06:04

Objective Nociceptive Assessment in Ventilated ICU Patients: A Feasibility Study Using Pupillometry and the Nociceptive Flexion Reflex

Published on: July 4, 2018

Classical Short-Delay Eyeblink Conditioning in One-Year-Old Children
07:36

Classical Short-Delay Eyeblink Conditioning in One-Year-Old Children

Published on: September 1, 2018

Area of Science:

  • Neuroscience
  • Pain Research

Background:

  • The blink reflex R2 response is typically evoked by both non-painful and painful stimuli.
  • Distinguishing between these stimulus types is crucial for understanding pain pathways.

Purpose of the Study:

  • To develop and evaluate a novel surface electrode for eliciting a nociception-specific R2 response.
  • To investigate the selective activation of nociceptive pathways using this new electrode.

Main Methods:

  • Blink reflex testing was performed on 10 healthy subjects.
  • Two electrode types were used: a standard electrode (10-15 mA) and a new concentric surface electrode (0.6-1.6 mA) designed to induce pin-prick pain.
  • Topical local anesthesia (lignocaine/prilocaine) was applied.

Main Results:

  • The R1 response remained unchanged after anesthesia.
  • The R2 response showed a 12% attenuation with standard stimulation.
  • The R2 response was significantly reduced (by 91%) with the new electrode type.

Conclusions:

  • The new electrode enables preferential depolarization of superficial nociceptive A-delta fibers due to high current density at low stimulus intensities.
  • This technique provides a less traumatic and effective method for studying trigeminal nociception.