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Magnetoelectric brain stimulation in the assessment of brain physiology and pathophysiology
1Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA. lsb21@columbia.edu
Objective:
To review findings from transcranial magnetic stimulation (TMS)-induced motor evoked potentials in normal subjects, in various neurological diseases and with pharmacologic manipulation.
Methods:
MEDLINE was searched to identify pertinent articles and articles referenced therein were also reviewed.
Results:
TMS is a safe and non-invasive technique which has been used widely in the study of corticospinal and corticocortical connectivity as well as in the assessment of basal ganglia disorders, diffuse diseases, and neuropharmacology.
Conclusions:
TMS motor measures have utility in examination of brain structure and function within and beyond the corticospinal tract. These measures have both research and clinical applications.