Markers of inflammation as predictors in cardiovascular disease

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Updated: Sep 30, 2026

On-Chip Endothelial Inflammatory Phenotyping
12:43

On-Chip Endothelial Inflammatory Phenotyping

Published on: July 21, 2012

F Van Lente1

  • 1Department of Clinical Pathology, The Cleveland Clinic Foundation, 9500 Euclid Ave., Cleveland, OH 44195, USA. vanlenf@ccf.org

Clinica Chimica Acta; International Journal of Clinical Chemistry
|March 4, 2000
PubMed

Insights

Inflammation in coronary arteries is key to atherosclerosis and acute coronary syndromes. Inflammatory markers in blood and tissue can predict cardiovascular disease risk and outcomes, complementing traditional factors.

Area of Science:

  • Cardiovascular Medicine
  • Inflammation Research
  • Biochemical Markers

Background:

  • Inflammation in coronary arteries is increasingly recognized as a central mechanism in atherosclerosis development.
  • Acute coronary syndromes are closely linked to ongoing inflammatory processes within the vasculature.

Purpose of the Study:

  • To review the role of biochemical markers of inflammation in predicting coronary heart disease (CHD) risk.
  • To assess the utility of inflammatory markers in predicting adverse cardiac outcomes in patients with established coronary syndromes.

Main Methods:

  • Review of experimental and clinical studies examining plasma and tissue biochemical markers of inflammation.
  • Analysis of studies investigating the predictive value of inflammatory markers independently and in conjunction with traditional cardiovascular risk factors.

Main Results:

  • Substantial evidence supports ongoing inflammation in coronary heart disease.
  • Inflammatory markers provide risk prediction information independent of and complementary to traditional cardiovascular disease risk factors.

Conclusions:

  • Biochemical markers of inflammation show potential for predicting coronary heart disease risk and adverse cardiac outcomes.
  • Further prospective studies are needed to clarify the roles of various inflammatory markers in the prediction, diagnosis, and management of cardiovascular disease.

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