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Updated: Aug 8, 2026

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
Published on: May 10, 2022
Total iron-binding capacity and serum transferrin determination under the influence of several clinical conditions
R Gottschalk1, R Wigand, C F Dietrich
1Medizinische Klinik III, Zentrum der Inneren Medizin, J.W. Goethe-Universität, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.
Abstract:
In this study TIBC and serum-transferrin concentrations were determined by immunochemical turbidimetry, immunochemical nephelometry and radial immunodiffusion under normal and pathological clinical conditions. A total of 246 (123 male/123 female) patients were included [iron deficiency: 60 (18/42), iron overload: 56 (39/17), chronic inflammation: 47 (23/24), undefined diseases: 35 (16/19), healthy volunteers 48 (27/21)]. The data show that determination of TIBC from conversion of transferrin values using a constant factor results in significantly higher values compared to conversion with a function of first degree. For clinical practice the influence of different diseases is negligible. This study indicates that it is not possible to develop a universal algorithm for the conversion of transferrin values into TIBC.
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