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Hypofractionation in glioblastoma multiforme.

M C Hulshof¹, E C Schimmel, D Andries Bosch

¹Department of Radiotherapy, Academic Medical Centre, University of Amsterdam, P.0. Box 22700, 1100 DE, Amsterdam, The Netherlands.

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology

|March 4, 2000

Summary

Extreme hypofractionation using 4x7 Gy conformal radiation therapy for glioblastoma multiforme patients with poor prognosis is well tolerated. This approach offers comparable palliative effects to conventional fractionation without negatively impacting survival.

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Area of Science:

Radiation Oncology
Neuro-oncology
Clinical Trials

Background:

Glioblastoma multiforme requires effective treatment strategies.
Conventional fractionation and hypofractionation are radiotherapy approaches.
Comparing these methods is crucial for optimizing patient outcomes.

Purpose of the Study:

To compare conventional fractionation with hypofractionation for glioblastoma multiforme.
To evaluate overall survival and palliative effects of different radiation schemes.

Main Methods:

Prospective analysis of 155 glioblastoma multiforme patients (1988-1998).
Exclusion of patients without irradiation or with interstitial boost.
Comparison of three radiation schemes: 33x2 Gy, 8x5 Gy, and 4x7 Gy.

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Main Results:

Median survival: 7 months (33x2 Gy), 5.6 months (8x5 Gy), 6.6 months (4x7 Gy).
Hypofractionation group had poorer prognostic factors.
Neurological improvement/stabilization was similar between 4x7 Gy and 33x2 Gy groups.

Conclusions:

Extreme hypofractionation (4x7 Gy) is well-tolerated and convenient for poor-prognosis glioblastoma patients.
This scheme provides equal palliation compared to conventional fractionation.
No negative impact on survival observed with extreme hypofractionation.