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Published on: February 20, 2017
Cutaneous fibrosis induced by docetaxel: a case report
M G Cleveland1, B S Ajaikumar, R Reganti
1Division of Dermatology, Burlington Medical Center, Burlington, IA 52601, USA.
Background:
Docetaxel is a taxoid antineoplastic agent approved for use in the treatment of metastatic breast carcinoma. The current study reports an unusual case of generalized cutaneous fibrosis in a 39-year-old white female after treatment with 18 cycles of docetaxel for metastatic breast carcinoma.
Methods:
Cutaneous fibrosis represents a rare and unique reaction associated with the cyclic use of docetaxel. The reaction is manifested by a distinct sequence of events involving pronounced edema followed by the rapid development of cutaneous fibrosis in dependent areas.
Results:
Cessation of therapy results in dramatic reversal of the fibrotic process.
Conclusions:
This case report further substantiates the belief that docetaxel represents one of a very limited number of agents that appear capable of giving rise to scleroderma-like features.
