Related Experiment Videos
Involvement of OSP/claudin-11 in oligodendrocyte membrane interactions: role in biology and disease
J M Bronstein1, S Tiwari-Woodruff, A G Buznikov
1Departments of Neurology and the Brain Research Institute, UCLA School of Medicine, Los Angeles, CA 90095, USA. jbronste@ucla.edu
Journal of Neuroscience Research
|March 4, 2000
Abstract:
Oligodendrocyte-specific protein (OSP/claudin-11) is a four transmembrane protein concentrated in central nervous system myelin. Recent evidence has emerged suggesting that OSP/claudin-11 is involved in membrane interactions at tight junctions and with the extracellular matrix. OSP/claudin-11 seems to modulate proliferation and migration of oligodendrocytes presumably through these interactions. Furthermore, evidence is presented implicating OSP/claudin-11 as an autoantigen in the development of autoimmune demyelinating disease.