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[Combination of levofolinate calcium and 5-fluorouracil]
1Dept. of Chemotherapy, Tokyo Metropolitan Komagome Hospital.
Gan to Kagaku Ryoho. Cancer & Chemotherapy
|March 4, 2000
Abstract:
It has been determined that in the combination of Leucovorin (LV) and 5-fluorouracil (5-FU), LV potentiates the cytotoxic effect of 5-FU based on biochemical modulation. Many data suggest that LV/5-FU is a very effective combination, and most clinicians worldwide now regard it as the standard therapy for colorectal cancer. In Japan, clinical examinations of this combination using Levofolinate calcium (I-LV) have shown its effectiveness, and I-LV/5-FU for gastric and colorectal cancer was authorized by the Ministry of Public Welfare in Oct. 1999.