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Related Experiment Videos

Abnormalities of renal function in the elderly.

P F Abreu1, L R Ramos, R Sesso

  • 1Division of Nephrology, Escola Paulista de Medicina, UNIFESP, São Paulo, Brazil.

Geriatric Nephrology and Urology
|March 4, 2000
PubMed
Summary
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Glomerular dysfunction and urinary abnormalities are common in the elderly. However, proximal tubular dysfunction is rare in this population, indicating a need for targeted renal health monitoring in aging individuals.

Area of Science:

  • Nephrology
  • Geriatrics
  • Internal Medicine

Background:

  • Aging is associated with physiological changes affecting renal function.
  • Understanding age-related changes in kidney function is crucial for geriatric care.
  • Urinary abnormalities can be indicators of underlying renal pathology in older adults.

Purpose of the Study:

  • To assess glomerular and proximal tubular renal function in the elderly population.
  • To determine the prevalence of various urinary abnormalities in older adults.
  • To identify potential links between renal function markers and urinary findings.

Main Methods:

  • A cross-sectional study was conducted in São Paulo.
  • A population-based sample of 81 elderly subjects (mean age 73.7 years) was analyzed.

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  • Key outcome measures included 24-h creatinine clearance (CCr), microalbuminuria, urinary retinol-binding protein (urRBP), leukocyturia, hematuria, and total proteinuria.

    • Main Results:

    • 68% of subjects had a CCr below 80 ml/min/1.73 m2, indicating glomerular dysfunction.
    • The prevalence of microalbuminuria was 31%, associated with higher systolic blood pressure and serum creatinine.
    • While urRBP was mostly normal, leukocyturia and hematuria were prevalent, particularly in females.

    Conclusions:

    • Glomerular dysfunction and various urinary abnormalities are frequent in the elderly.
    • Proximal tubular dysfunction, as indicated by urRBP, appears uncommon in this age group.
    • These findings highlight the importance of monitoring glomerular function and detecting urinary abnormalities in elderly individuals.