Studies on the excretion of doxycycline in patients with ileostomies

The excretion of doxycycline was studied in patients with ileostomies after intravenous administration of the drug. The intestinal excretion, measured by bioassay, was of the same magnitude as reported in normal human beings when similar methods have been used. If the main part of a dose of doxycycline is secreted and bound in the intestine, this study suggests that the large bowel is not important for this binding.