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Related Experiment Videos

Maternal and mating-induced aggression is associated with elevated citrulline immunoreactivity in the paraventricular

S C Gammie1, R J Nelson

  • 1Department of Psychology, The Johns Hopkins University, Baltimore, Maryland 21218, USA. sgammie@jhu.edu

The Journal of Comparative Neurology
|March 4, 2000
PubMed
Summary

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Nitric oxide (NO) synthesis increases in the paraventricular nucleus (PVN) during maternal aggression in female prairie voles and mating-induced aggression in males. This suggests NO plays a specific role in these aggressive behaviors.

Area of Science:

  • Neuroscience
  • Behavioral Endocrinology
  • Animal Behavior

Background:

  • Rodent maternal aggression is crucial for pup survival.
  • Prairie vole males exhibit mating-induced aggression linked to reproduction.
  • Nitric oxide (NO) influences aggression, potentially differently in males and females.

Purpose of the Study:

  • To investigate the role of NO synthesis in maternal and mating-induced aggression in prairie voles.
  • To examine NO synthesis indirectly by measuring citrulline, a marker of NO production.
  • To determine if NO synthesis is localized to specific brain regions during these aggressive states.

Main Methods:

  • Aggressive behavioral testing in female and male prairie voles.
  • Immunohistochemistry for citrulline to assess NO synthesis.

Related Experiment Videos

  • Comparison of citrulline-positive cell counts in brain regions between aggressive and non-aggressive states.

    • Main Results:

    • Increased citrulline-positive cells in the paraventricular nucleus (PVN) of aggressive lactating females compared to controls.
    • Increased citrulline-positive cells in the PVN of aggressive mated males compared to non-aggressive males.
    • No changes in citrulline immunoreactivity in other brain regions.

    Conclusions:

    • NO synthesis is specifically elevated in the PVN during maternal aggression in female prairie voles.
    • NO synthesis is also elevated in the PVN during mating-induced aggression in male prairie voles.
    • These findings suggest a critical role for NO in the PVN for both maternal and mating-induced aggression in this species.