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Flow-injection extraction-spectrophotometric method for the determination of chlorhexidine in pharmaceutical
T Pérez-Ruiz1, C Martínez-Lozano, A Sanz
1Department of Analytical Chemistry, Faculty of Chemistry, University of Murcia, Spain. tpr@fcu.um.es
Journal of Pharmaceutical and Biomedical Analysis
|March 4, 2000
Abstract:
The spectrophotometric determination of trace amounts of chlorhexidine was carried out by liquid-liquid extraction using bromophenol blue with a flow system. The determination of chlorhexidine in the range of 1 x 10(-4) to 1 x 10(-5) M was possible with a sampling frequency of 40 samples per hour. The method was satisfactorily applied to the determination of chlorhexidine in pharmaceutical preparations.