Transfer from manual to automated sample preparation: a case study
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Updated: Oct 17, 2026

Automated Sample Multiplexing by using Combined Precursor Isotopic Labeling and Isobaric Tagging (cPILOT)
Published on: December 18, 2020
1Pharmaceutical Technologies, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA. soon_m_han@sbphrd.com
Abstract:
A manual sample preparation for a controlled release capsule formulation has been converted to an automated sample preparation. Each step of the manual sample preparation was evaluated as to its feasibility for automation in terms of precision, carryover, filter selection and other critical issues. Although most steps of the manual method were easily translated to the automated procedure, certain 'simple' details such as filter selection, sample storage, and the conversion from volumetric to gravimetric measurements needed closer investigation.
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