Kinases of the Src family: structure and functions

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Published on: August 29, 2015

A G Tatosyan1, O A Mizenina

  • 1Institute of Carcinogenesis, Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow, 115478, Russia. tatosyan@space.ru

Biochemistry. Biokhimiia
|March 7, 2000
PubMed

Insights

Src family tyrosine kinases regulate cell growth, differentiation, and adhesion. This review details the structure, substrates, and regulatory mechanisms of these nonreceptor tyrosine kinases, focusing on the Src protein and its relatives.

Area of Science:

  • Cellular Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Src family tyrosine kinases are crucial regulators of intracellular signal transduction pathways.
  • These kinases play vital roles in fundamental cellular processes including growth, differentiation, adhesion, and transcription.
  • Aberrant activity or structure of Src proteins can lead to oncogenic transformation.

Purpose of the Study:

  • To provide a comprehensive review of the Src family of nonreceptor tyrosine kinases.
  • To elucidate the structure, substrates, and regulatory mechanisms of these enzymes.
  • To highlight the role of Src family kinases in cellular functions and disease, using the Src gene product as a model.

Main Methods:

  • Literature review and data synthesis.
  • Analysis of existing research on Src family tyrosine kinases.
  • Comparative examination of the Src gene product and related proteins.

Main Results:

  • Src family tyrosine kinases are characterized by specific structural features that influence their function.
  • A diverse range of substrates are regulated by these kinases, impacting multiple signaling cascades.
  • Complex regulatory mechanisms control the activity of Src family kinases, ensuring proper cellular signaling.

Conclusions:

  • The Src family of nonreceptor tyrosine kinases are key players in cellular signaling networks.
  • Understanding their structure, substrates, and regulation is critical for comprehending normal cell function and oncogenesis.
  • Further research into Src family kinases holds potential for therapeutic interventions in cancer and other diseases.

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