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Leptin deficiency due to lipid apheresis: a possible reason for ravenous hunger and weight gain
G C Leitner1, J M Roob, B Bahadori
1Division of Nephrology, Karl-Franzens University, Graz, Austria. gerhard.leitner@kfunigraz.ac.at
Objective:
To investigate how extracorporal cholesterol lowering therapy affects circulating leptin levels in patients with ravenous hunger after treatment and permanent weight gain.
Design:
A case report.
Subject:
51 y old caucasian male patient with moderate chronic renal failure.
Measurements:
Serum Leptin concentration (RIA, Linco Research Inc, St. Louis, MO, USA), total cholesterol, low density lipoprotein cholesterol, blood glucose levels, calorie intake by food records.
Results:
During treatment total cholesterol was reduced by 50%. Serum Leptin levels showed a 42% reduction at the end of treatment, that by far exceeds the physiological diurnal variation. Calorie intake was significantly increased on days of treatment.
Conclusion:
We conclude that this artificial reduction in circulating leptin plays an important role in the pathogenesis of ravenous hunger and weight gain under extracorporal cholesterol lowering therapy in this case.
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