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[Effect of ionizing radiation on functional activity of macrophagesĭ]
S G Zubova1, T B Bykova, A Iu Zaritskii
1N.N. Petrov Research Institute of Oncology, Ministry of Health of the RF, St. Petersburg.
Voprosy Onkologii
|March 7, 2000
Abstract:
It was shown that in vitro irradiation (8 Gy) of murine peritoneal macrophages suppressed their spontaneous cytotoxity and induced growth-stimulating activity. Exposure to 4 Gy induced mRNA proximal factors--TGF-beta and TNF-alpha and boosted growth-stimulating activity. These effects should be considered when evaluating efficacy of radiotherapy for tumors.