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Related Experiment Videos

[Ten-year experience with intraoperative radiotherapy].

B N Zyrianov1, S G Afanas'ev, A A Zav'ialov

  • 1Research Institute of Oncology, Research Center of Russian Academy of Medical Sciences, Tomsk.

Voprosy Onkologii
|March 7, 2000
PubMed
Summary

Intraoperative radiation therapy (IORT) combined with surgery improved survival rates for stage III non-small cell lung cancer and gastric cancer patients. IORT also reduced recurrence in soft-tissue sarcoma patients.

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[The analysis of perioperative period in patients with lung cancer stage III, receiving the combined treatment].

Khirurgiia·2013

Area of Science:

  • Oncology
  • Surgical Oncology
  • Radiation Oncology

Context:

  • Stage III non-small cell lung cancer, gastric cancer, and soft-tissue sarcoma present significant treatment challenges.
  • Radical surgery is a primary treatment modality for these advanced cancers.
  • Optimizing adjuvant therapies to improve patient outcomes remains a critical area of research.

Purpose:

  • To evaluate the efficacy of intraoperative radiation therapy (IORT) as an adjunct to radical surgery for stage III cancers.
  • To assess the impact of IORT on survival rates and recurrence incidence in non-small cell lung cancer, gastric cancer, and soft-tissue sarcoma.
  • To determine the safety profile of IORT, specifically regarding wound healing and postoperative lethality.

Summary:

  • A study analyzed the outcomes of radical surgery combined with intraoperative radiation therapy (IORT) using a small-size betatron (10-20 Gy single dose).

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  • For stage III non-small cell lung cancer, 5-year survival increased from 24.4% (surgery alone) to 34.1% (surgery + IORT).
  • Stage III gastric cancer patients showed a 5-year survival of 34.2% with IORT versus 21.7% with surgery alone. Soft-tissue sarcoma patients experienced reduced local recurrence with IORT.

    • Impact:

    • IORT demonstrates a significant benefit in improving long-term survival for patients with stage III non-small cell lung cancer and gastric cancer.
    • The integration of IORT into surgical procedures for soft-tissue sarcomas effectively reduces local recurrence rates.
    • Intraoperative radiation therapy is a safe and effective adjuvant treatment, not compromising wound healing or increasing postoperative mortality.