Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Receptor-ligand interaction and molecular modelling.

V Hornák1, R Dvorský, E Sturdík

  • 1Institute of Molecular Biology, Slovak Academy of Sciences, Bratislava. umbivhor@savba.savba.sk

General Physiology and Biophysics
|March 7, 2000
PubMed
Summary

This paper reviews computational methods for describing ligand-receptor interactions. It covers established tools for qualitative and quantitative analysis, applicable with or without known receptor structures.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Tandem Reconnection and Cusp Electrodynamics Reconnaissance Satellites (TRACERS) Mission.

Space science reviews·2025
Same author

Specific mosaic KRAS mutations affecting codon 146 cause oculoectodermal syndrome and encephalocraniocutaneous lipomatosis.

Clinical genetics·2016
Same author

Degradation of Delor 103, a technical mixture of polychlorinated biphenyls, by selected bacteria.

World journal of microbiology & biotechnology·2014
Same author

Influence of carbohydrates and polyols on L-lactic acid production and fatty acid formation by Rhizopus arrhizus.

World journal of microbiology & biotechnology·2014
Same author

Effect of growth supplements and whey pretreatment on butyric acid production by Clostridium butyricum.

World journal of microbiology & biotechnology·2014
Same author

Preparation of silicon nanoparticular nanocomposite with thin interparticular tin matrix.

Journal of nanoscience and nanotechnology·2012

Area of Science:

  • Computational chemistry
  • Molecular modeling
  • Drug discovery

Background:

  • Ligand-receptor interactions are crucial in biological processes and drug development.
  • Accurate computational methods are needed to understand these interactions.
  • Recent advancements have expanded the toolkit for analyzing these molecular complexes.

Purpose of the Study:

  • To review computational methods for describing ligand-receptor interactions.
  • To present established tools for qualitative and quantitative analysis.
  • To illustrate applications in specific scenarios.

Main Methods:

  • Review of computational techniques for molecular interaction analysis.
  • Categorization of methods based on receptor structure availability (known vs. unknown).

Related Experiment Videos

  • Case study examples demonstrating methodological applications.

    • Main Results:

    • Established computational methods provide valuable insights into ligand-receptor binding.
    • The reviewed techniques are applicable across diverse scenarios, including those with incomplete structural data.
    • Methodological applications highlight their utility in specific, challenging cases.

    Conclusions:

    • A decade of advancements has yielded robust computational tools for ligand-receptor interaction studies.
    • These methods are essential for both qualitative and quantitative assessments in molecular modeling.
    • The reviewed approaches offer practical solutions for understanding molecular recognition in various contexts.