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Interaction with human immunodeficiency virus (HIV) type 2 predicts HIV type 1 genotype
A D Sarr1, J L Sankalé, D J Hamel
1Department of Immunology, Harvard AIDS Institute, Harvard School of Public Health, 651 Huntington Avenue, Boston, Massachusetts, 02115, USA.
Virology
|March 8, 2000
Summary
Dual infections with human immunodeficiency virus type 1 (HIV-1) and HIV-2 in Senegal were linked to a distinct HIV-1 subtype A genotype. This suggests variations in biological properties influence HIV-1 and HIV-2 interactions.
Area of Science:
- * Virology
- * Epidemiology
- * Immunology
Background:
- * Human immunodeficiency virus type 1 (HIV-1) and HIV-2 cocirculate in West Africa, India, and parts of Europe.
- * Understanding HIV-1 subtypes in dual infections is crucial for public health strategies.
Purpose of the Study:
- * To identify HIV-1 subtypes involved in dual HIV-1 and HIV-2 infections.
- * To investigate the association between specific HIV-1 genotypes and co-infection with HIV-2.
Main Methods:
- * Sequencing of the envelope C2-V3 region from 29 dually infected female commercial sex workers in Senegal.
- * Phylogenetic analysis to determine HIV-1 subtype clustering.
Main Results:
- * The majority of dually infected individuals (23/29) harbored HIV-1 subtype A.
- * A significant proportion (14/23) of subtype A sequences clustered with the A/G recombinant form (IbNG).
- * A distinct cluster of non-IbNG subtype A was observed in dually infected individuals compared to singly infected individuals (39.2% vs. 13.3%).
Conclusions:
- * A specific HIV-1 subtype A genotype is associated with dual HIV-1 and HIV-2 infections.
- * These findings suggest differential biological properties of HIV-1 genotypes influencing interactions with HIV-2 in vivo.