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Related Experiment Videos

Olfactory neurons are interdependent in maintaining axonal projections.

F A Ebrahimi1, A Chess

  • 1Department of Biology, Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, Masachusetts 02142, USA.

Current Biology : CB
|March 8, 2000
PubMed
Summary

Olfactory receptor projections converge to form glomeruli. In adult mice, this convergence is maintained by the presence of similar axons, a phenomenon termed interdependence.

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Area of Science:

  • Neuroscience
  • Olfactory system biology
  • Molecular biology

Background:

  • Individual olfactory neurons express one of thousands of olfactory receptor genes.
  • Axons from neurons expressing the same receptor converge to form glomeruli in the olfactory bulb.
  • The mechanisms maintaining glomerular structure in adulthood are not well understood.

Purpose of the Study:

  • To investigate the mechanisms maintaining axonal convergence and glomerular structure in the adult olfactory bulb.
  • To determine if olfactory receptor gene expression is sufficient for maintaining glomerular structure.
  • To explore the phenomenon of axonal interdependence in the olfactory system.

Main Methods:

  • Utilized a transgenic olfactory receptor locus functioning independently of endogenous loci in mice.

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  • Observed axonal projections and glomerular formation in both newborn and adult mice.
  • Correlated the number of neurons expressing the transgenic receptor with the maintenance of convergence.

    • Main Results:

    • Axonal projections expressing the transgenic olfactory receptor converged in newborn mice.
    • Glomerular convergence was not consistently maintained in adult mice.
    • A positive correlation was found between the number of expressing neurons and the probability of maintaining convergence in adults.

    Conclusions:

    • Olfactory neurons require the presence of similar axons to maintain glomerular structure.
    • Axonal convergence in the olfactory bulb exhibits interdependence, particularly in adulthood.
    • This interdependence is crucial for the stability of olfactory sensory maps.