Related Experiment Videos
Pseudopapilledema in neurofibromatosis type 2
1Departments of Ophthalmology and Visual Sciences and Pediatrics, St Louis Children's Hospital, Washington University School of Medicine, St Louis, MO 63110, USA. luederg@seer.wustl.edu
Purpose:
To report a case of neurofibromatosis type 2 with pseudopapilledema secondary to a prepapillary gliotic membrane.
Method:
Case report. Results of an ocular examination and fluorescein angiography of a patient are described.
Results:
Fundus examination of a 14-year-old male with neurofibromatosis type 2 revealed an irregular elevation of the optic nerve and a perifoveal epiretinal membrane in the right eye. Fluorescein angiography demonstrated no autofluorescence nor leakage in the area of the optic nerve.
Conclusion:
The patient has pseudopapilledema secondary to an epiretinal membrane overlying the optic disk of the right eye. The possibility of pseudopapilledema should be considered when evaluating patients with neurofibromatosis type 2 and abnormal optic nerves.
Insights
Neurofibromatosis type 2 can cause pseudopapilledema due to epiretinal membranes. This case highlights the importance of considering pseudopapilledema in NF2 patients with optic nerve abnormalities.
Area of Science:
- Ophthalmology
- Neuro-oncology
- Genetics
Background:
- Neurofibromatosis type 2 (NF2) is a genetic disorder characterized by the development of tumors in the nervous system.
- Optic nerve abnormalities can occur in NF2 patients, necessitating careful differential diagnosis.
Observation:
- A 14-year-old male with NF2 presented with fundus examination findings suggestive of optic nerve elevation in the right eye.
- A perifoveal epiretinal membrane was noted overlying the optic disc.
Findings:
- Ocular examination revealed irregular optic nerve elevation and a prepapillary epiretinal membrane.
- Fluorescein angiography showed no abnormal autofluorescence or leakage, ruling out optic disc edema.
Implications:
- This case illustrates pseudopapilledema as a manifestation of NF2, secondary to a prepapillary gliotic membrane.
- Clinicians should consider pseudopapilledema in the differential diagnosis of optic nerve abnormalities in patients with NF2.