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Related Experiment Videos

Increased plasma homocysteine after menopause.

A E Hak1, K H Polderman, I C Westendorp

  • 1Department of Epidemiology and Biostatistics, Erasmus University Medical School, P.O. Box 1738, 3000 DR, Rotterdam, The Netherlands.

Atherosclerosis
|March 8, 2000
PubMed
Summary

Menopause is associated with increased plasma homocysteine levels. This study found a 7% higher homocysteine level in postmenopausal women compared to premenopausal women, independent of age and other factors.

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Area of Science:

  • Endocrinology
  • Cardiovascular Health
  • Nutritional Biochemistry

Background:

  • Elevated plasma homocysteine is a risk factor for cardiovascular disease.
  • Menopause and sex steroid hormones may influence homocysteine levels, but previous studies had inconsistent findings and did not adequately control for age.
  • Age is a significant confounder in studies investigating menopause and homocysteine.

Purpose of the Study:

  • To investigate the relationship between menopausal status and plasma homocysteine levels.
  • To minimize confounding factors, particularly age, by comparing age-matched premenopausal and postmenopausal women.
  • To determine if menopause independently affects plasma homocysteine.

Main Methods:

  • A population-based study involving 93 premenopausal and 93 age-matched postmenopausal women (aged 43-55 years).

Related Experiment Videos

  • Women were selected from a larger cohort based on menopausal status and regular menses.
  • Plasma homocysteine levels were measured in a fasting state and adjusted for age and other potential confounders.

    • Main Results:

    • A statistically significant difference in plasma homocysteine levels was observed between premenopausal and postmenopausal women (P = 0.04).
    • The age-adjusted geometric mean homocysteine level was 7% higher in postmenopausal women (11.5 micromol/l) compared to premenopausal women (10.7 micromol/l).
    • This difference remained significant after adjusting for plasma creatinine, body mass index, smoking, and alcohol intake.

    Conclusions:

    • Menopausal status is an independent factor affecting plasma homocysteine levels.
    • Postmenopausal women exhibit higher plasma homocysteine concentrations compared to their premenopausal counterparts.
    • These findings highlight a potential hormonal influence on homocysteine metabolism related to menopause.