No evidence of correlation between mutation at codon 531 of src and the risk of colon cancer in Chinese

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N M Wang1, K T Yeh, C H Tsai

  • 1Division of Molecular Medicine, Department of Medical Research, China Medical College Hospital, Taichung, Taiwan.

Cancer Letters
|March 8, 2000
PubMed

Insights

This study investigated a specific src gene mutation linked to colon cancer risk. Researchers found no evidence of this mutation in Chinese patients, suggesting it is not a significant factor in colon cancer development within this population.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Elevated protein tyrosine kinase activity of pp60(c-src) is observed in various human cancers, including colon cancer.
  • Phosphorylation at tyrosine 530 normally suppresses pp60(c-src) kinase activity.
  • A C-->T transition mutation at codon 531 (Gln-531-->Amber-531) in the src gene was previously suggested to increase colon cancer risk by causing premature translation termination and up-regulating kinase activity.

Purpose of the Study:

  • To investigate whether the Gln-531-->Amber-531 src gene mutation is a risk factor for colon carcinoma in the Chinese population.

Main Methods:

  • A PCR-based assay was employed to analyze the src genotypes.
  • The study screened 131 cases of colon cancer and various other carcinomas.

Main Results:

  • No instances of the Gln-531-->Amber-531 src gene mutation were detected in any of the screened Chinese specimens.

Conclusions:

  • The src gene mutation at Gln-531 does not appear to be implicated in the development of colon cancer among the Chinese population studied.

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