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Interleukin-18: biological properties and clinical implications.

S Lebel-Binay1, A Berger, F Zinzindohoué

  • 1Luti/Laboratoire de Recherche Chirurgicale, Bât. Gustave-Roussy, 3e étage, Hôpital Cochin, 27, rue du Faubourg-St-Jacques, 75014 Paris, France. sophie.lebel-binay@cochin.univ-paris5.fr

European Cytokine Network
|March 8, 2000
PubMed
Summary

Interleukin-18 (IL-18), a pro-inflammatory cytokine, plays a key role in immune responses. This review explores IL-18

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Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Biology

Background:

  • Interleukin-18 (IL-18), initially known as interferon-gamma inducing factor (IGIF), shares structural and functional similarities with the IL-1 family.
  • IL-18 is functionally linked to IL-12, promoting Th1 cytokine production and cell-mediated immune cytotoxicity.

Purpose of the Study:

  • To review recent advancements in understanding IL-18.
  • To focus on the role of IL-18 modulation in various diseases.

Main Methods:

  • Literature review of recent scientific advances.
  • Synthesis of information on IL-18 structure, processing, receptor expression, and immunoregulatory functions.

Main Results:

  • IL-18 exhibits pro-inflammatory properties and influences immune responses.

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  • IL-18 modulation is implicated in the pathogenesis and potential treatment of tumors, infections, and autoimmune/inflammatory diseases.

    • Conclusions:

    • IL-18 is a critical cytokine with diverse roles in immunity and disease.
    • Further research into IL-18 modulation holds therapeutic potential for a range of conditions.