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Bronchial reactivity in subjects with urticaria
1Department of Internal Medicine, Turin University, Italy.
Panminerva Medica
|March 8, 2000
Summary
This study investigated airway inflammation in chronic urticaria patients with negative allergy tests. Results showed no significant bronchial hyperreactivity, suggesting respiratory monitoring is unnecessary for these individuals.
Area of Science:
- Immunology
- Pulmonology
- Dermatology
Background:
- Respiratory symptoms like asthma can be linked to skin diseases with allergic origins.
- However, some chronic urticaria patients lack clear immunological or allergic triggers.
- This study explores potential airway inflammation in such cases.
Purpose of the Study:
- To investigate the presence of airway inflammation in patients with chronic urticaria and negative immunological/allergological findings.
- To determine if bronchostimulation testing is warranted in these individuals.
Main Methods:
- Nonspecific bronchostimulation using methacholine was performed on 12 subjects with chronic urticaria.
- Subjects had previously shown negative immunological and allergological test results.
- Forced expiratory volume in 1 second (FEV1) was used to evaluate the bronchostimulation test.
Main Results:
- All 12 subjects demonstrated normal bronchoreactivity, with a mean provocative dose 20 (PD20) of 1400 micrograms.
- The methacholine bronchostimulation test results were consistently negative.
- The control group exhibited a mean PD20 of 720 micrograms.
Conclusions:
- The absence of bronchial hyperreactivity in these chronic urticaria patients indicates that respiratory function monitoring is likely not required.
- This finding helps refine diagnostic and management strategies for chronic urticaria.