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Auditory P300 event related potential in minor ischemic stroke
J T Korpelainen1, M L Kauhanen, U Tolonen
1Department of Rehabilitation, Deaconess Institute of Oulu, Finland.
Acta Neurologica Scandinavica
|March 8, 2000
Summary
Ischemic stroke delays P300 event-related potentials (ERPs) and temporarily disrupts age-related correlations. This P300 latency increase is linked to post-stroke depression, impacting cognitive function.
Area of Science:
- Neuroscience
- Cognitive Psychology
- Neurology
Background:
- Abnormalities in cognitive event-related potentials (ERPs) can indicate various cerebral diseases and depression.
- The P300 component of ERPs is a key indicator of cognitive processing.
Purpose of the Study:
- To investigate the impact of ischemic stroke on the P300 ERP component.
- To determine the relationship between stroke-related P300 changes and post-stroke depression.
Main Methods:
- P300 waves were recorded using an auditory oddball paradigm.
- 38 mild ischemic stroke patients and 29 healthy controls were studied at 3 and 12 months post-stroke.
- Depression was assessed using the Zung Depression Scale and DSM-III criteria.
Main Results:
- Ischemic stroke led to a slight prolongation of P300 latency, which correlated with post-stroke depression severity.
- P300 amplitude and scalp distribution remained unaffected by infarction.
- Age-P300 latency correlation was absent at 3 months but present at 12 months post-stroke.
Conclusions:
- Ischemic stroke delays P300 ERP latency and temporarily alters its age-related physiological patterns.
- Increased P300 latency following stroke appears associated with depression.