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Serial intelligence test scores in pediatric moyamoya disease
C Imaizumi1, T Imaizumi, M Osawa
1Imaizumi Pediatric Clinic, Gunma, Maebashi-shi, Japan.
Neuropediatrics
|March 8, 2000
Summary
Intelligence in children with moyamoya disease declines after symptom onset. IQ scores decrease significantly within 5-10 years and stabilize thereafter, indicating a long-term impact.
Area of Science:
- Neurology
- Pediatrics
- Neuropsychology
Background:
- Moyamoya disease is a rare, progressive cerebrovascular disorder affecting children.
- Understanding the long-term cognitive impact of moyamoya disease is crucial for patient management.
Purpose of the Study:
- To evaluate the longitudinal changes in intelligence quotient (IQ) scores in children diagnosed with moyamoya disease.
Main Methods:
- Serial IQ tests were administered to 38 pediatric patients with moyamoya disease.
- IQ scores were analyzed across three time periods post-symptom onset: 0-5 years, 5-10 years, and >10 years.
- Mean IQ scores were calculated for patients with multiple tests within each period.
Main Results:
- IQ scores were significantly lower in the 5-10 years (76.8 ± 23.1) and >10 years (73.9 ± 31.1) categories compared to the 0-5 years category (92.9 ± 22.7).
- Five out of 10 patients tested multiple times in the 0-5 years category showed declining IQ scores.
- No significant difference in IQ scores was observed between the 5-10 years and >10 years categories.
Conclusions:
- Intelligence in pediatric moyamoya disease patients declines after symptom onset.
- The decline in IQ appears to stabilize more than 10 years after the onset of symptoms.
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