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Cytotoxic alkaloids of Pachysandra terminalis
S Funayama1, T Noshita, K Shinoda
1Department of Bioscience and Biotechnology, Aomori University, Japan.
Biological & Pharmaceutical Bulletin
|March 8, 2000
Abstract:
Four steroidal alkaloids, epipachysamines B (1) and E (2), pachystermine A (3) and pachysamine E (4), were isolated as cytotoxic principles from the MeOH extract of the stems of Pachysandra terminalis SIEB. et ZUCC. (Buxaceae). These alkaloids showed cytotoxic activity against P388 and P388/ADR leukemia cells in vitro. Three of the alkaloids (1-3) were previously isolated from this plant material, and this is the first report of their cytotoxic activity. Pachysamine E (4) is a new alkaloid.