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Drug-polymer conjugates containing acid-cleavable bonds.

F Kratz1, U Beyer, M T Schütte

  • 1Department of Medical Oncology, Clinical Research, Tumor Biology Center, Freiburg, Germany. felix@tumorbio.uni-freiburg.de

Critical Reviews in Therapeutic Drug Carrier Systems
|March 8, 2000
PubMed
Summary

Acid-sensitive drug-polymer conjugates offer targeted cancer treatment by releasing drugs in acidic tumor environments. This review covers 20 years of development and future directions for these advanced drug delivery systems.

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Area of Science:

  • Biomaterials Science
  • Drug Delivery
  • Oncology

Background:

  • Drug-polymer conjugates are investigated for targeted anticancer drug delivery.
  • Acid-sensitive linkers facilitate drug release in tumor microenvironments.
  • Tumor acidity enables both extracellular and intracellular drug release.

Purpose of the Study:

  • To review acid-sensitive drug-polymer conjugates developed over the last two decades.
  • To outline future research directions in this field.

Main Methods:

  • Literature review of acid-sensitive drug-polymer conjugates.
  • Analysis of drug release mechanisms based on pH sensitivity.

Main Results:

  • Acid-sensitive drug-polymer conjugates demonstrate potential for selective anticancer agent delivery.

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  • Drug release can be triggered by extracellular tumor acidity or intracellular acidic organelles.
  • Significant advancements have been made in the design and application of these conjugates.

    • Conclusions:

    • Acid-sensitive drug-polymer conjugates are a promising strategy for enhanced cancer therapy.
    • Further research is needed to optimize conjugate design and clinical translation.
    • Exploiting tumor acidity remains a key approach for effective drug release.