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Related Experiment Videos

Benchmark concentrations for methylmercury obtained from the Seychelles Child Development Study.

K S Crump1, C Van Landingham, C Shamlaye

  • 1The K.S. Crump Group, Inc., ICF Kaiser, Ruston, Louisiana 71270, USA.

Environmental Health Perspectives
|March 8, 2000
PubMed
Summary

Methylmercury exposure from fish is a concern for pregnant women. A new analysis of Seychelles data suggests safe maternal mercury hair levels are around 25 ppm, a benchmark dose lower confidence limit (BMDL).

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Area of Science:

  • Environmental toxicology
  • Neuroscience
  • Developmental toxicology

Background:

  • Methylmercury, a neurotoxin, poses risks to developing fetuses, primarily through fish consumption.
  • Existing reference doses for methylmercury have limitations, using data from high-level, short-term exposures or potentially insensitive metrics like mean exposure levels.

Purpose of the Study:

  • To re-evaluate methylmercury exposure levels in pregnant women using data from the Seychelles Child Development Study.
  • To establish a more robust benchmark dose lower confidence limit (BMDL) for methylmercury exposure based on neurologic and developmental outcomes in children.

Main Methods:

  • Conducted a benchmark dose analysis on neurologic test data and developmental milestones from children aged 6 to 66 months.
  • Modeled continuous and quantal data, exploring various dose-response models and covariate sets.

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  • Calculated 144 lower statistical bounds on the benchmark dose (BMDLs) for maternal mercury hair levels.

    • Main Results:

    • The average BMDL across 144 analyses was 25 parts per million (ppm) of mercury in maternal hair.
    • The range of BMDLs was 19 to 30 ppm, indicating a potential threshold for adverse effects.

    Conclusions:

    • Benchmark dose modeling provides an alternative to traditional reference doses for methylmercury.
    • Findings suggest that maternal mercury hair levels around 25 ppm may represent a level below which adverse neurodevelopmental effects are unlikely.