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Published on: June 26, 2020
Hepatitis viral infection in Behçet's disease
1Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, Japan
Summary
Hepatitis B virus (HBV) and GB virus C (GBV-C) DNA were found more frequently in Behçet
Area of Science:
- Virology
- Immunology
- Rheumatology
Background:
- Behçet's disease (BD) is a multisystem inflammatory disorder of unknown etiology.
- The potential role of viral infections, particularly hepatitis viruses, in BD pathogenesis requires further investigation.
Purpose of the Study:
- To investigate the association between hepatitis viral infections and Behçet's disease.
- To compare the prevalence of hepatitis viral markers and nucleic acids in BD patients and healthy controls.
Main Methods:
- Sera from 68 BD patients and 76 age/sex-matched blood donors were tested for hepatitis A, B, C, and GBV-C viral markers and nucleic acids.
- Hepatitis viral markers (anti-HA, HBsAg, anti-HBs, anti-HBc) and viral nucleic acids (HBV-DNA, HCV-RNA, GBV-C-RNA, TTV-DNA) were quantified.
Main Results:
- Hepatitis B virus (HBV)-DNA was significantly more prevalent in BD patients (11.8%) than in controls (2.6%).
- GB virus C (GBV-C)-RNA was also higher in BD patients (5.9%) compared to controls (0%).
- No significant differences were observed for hepatitis A, C, or TT virus markers between groups.
Conclusions:
- Hepatitis B virus and GB virus C infections may play a role in the pathogenesis of Behçet's disease.
- Further research is needed to elucidate the specific mechanisms linking these viral infections to BD development.
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