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Antituberculosis activity of certain antifungal and antihelmintic drugs
1Department of Molecular Microbiology and Immunology, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, MD 21205, USA. yzhang@jhsph.edu
Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
|March 9, 2000
Abstract:
A panel of antifungal and antihelmintic drugs was tested for activity against Mycobacterium tuberculosis in vitro. Antifungal drugs, miconazole, 2-nitroimidazole, clotrimazole, and the antihelmintic drug niclosamide were found to have significant antituberculosis activity, with minimal inhibitory concentrations (MICs) between 1 and 10 micrograms/ml. Niclosamide and 2-nitroimidazole also had activity against stationary phase tubercle bacilli. Further testing of these drugs and their derivatives in vitro and in vivo appears to be warranted.