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Decrease in serum ALT and increase in serum HCV RNA during pregnancy in women with chronic hepatitis C.

A Gervais1, Y Bacq, J Bernuau

  • 1Service d'Hépatologie, INSERM U481 and Centre de Recherche Claude Bernard sur les Hépatites Virales, Hôpital Beaujon, Clichy, France. gervais@bichat.inserm.fr

Journal of Hepatology
|March 9, 2000
PubMed
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Chronic hepatitis C in pregnant women shows decreasing alanine aminotransferase levels and increasing HCV RNA levels during pregnancy. These changes were not seen in non-pregnant controls.

Area of Science:

  • Hepatology
  • Virology
  • Obstetrics

Background:

  • The natural history of chronic hepatitis C during pregnancy remains unclear.
  • Understanding viral dynamics and liver enzyme changes is crucial for managing pregnant patients.

Purpose of the Study:

  • To assess changes in serum alanine aminotransferase (ALT) and hepatitis C virus (HCV) RNA levels during pregnancy.
  • To establish the natural history of chronic hepatitis C infection in pregnant women.

Main Methods:

  • Studied 26 pregnant women with chronic hepatitis C, monitoring ALT monthly during and around pregnancy.
  • Quantified serum HCV RNA levels in 12 women using branched DNA assay.
  • Compared findings with 26 age-matched non-pregnant women with chronic hepatitis C.

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Main Results:

  • Serum ALT levels decreased significantly in the second and third trimesters of pregnancy (p=0.0001).
  • Serum HCV RNA levels increased significantly in the second and third trimesters (p=0.01).
  • No significant changes in ALT or HCV RNA were observed in the control group.

Conclusions:

  • Pregnant women with chronic hepatitis C experience decreased serum ALT and increased serum HCV RNA levels during the second and third trimesters.
  • These findings highlight specific physiological adaptations during pregnancy in chronic hepatitis C patients.