Related Experiment Video
Updated: Aug 12, 2026
08:56
Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
Published on: April 7, 2023
Management of corticosteroid-induced osteoporosis
J D Adachi1, W P Olszynski, D A Hanley
1Department of Medicine, St Joseph's Hospital, McMaster University, Hamilton, Ontario, Canada.
Seminars in Arthritis and Rheumatism
|March 9, 2000
Summary
Bisphosphonates are the top choice for preventing and treating corticosteroid-induced osteoporosis, offering significant benefits despite unclear bone loss mechanisms. Other therapies may be considered for persistent bone loss.
Area of Science:
- Endocrinology
- Bone Metabolism
- Pharmacology
Background:
- Corticosteroids are widely used but can cause significant bone loss.
- Corticosteroid-induced osteoporosis (CIOP) is a common and serious side effect.
- Understanding the effects of corticosteroids on bone is crucial for patient management.
Purpose of the Study:
- To educate scientists and healthcare providers on corticosteroid effects on bone.
- To advise clinicians on appropriate treatments for CIOP.
- To review current management strategies for CIOP.
Main Methods:
- Systematic review of published articles on CIOP.
- Summary of pathophysiology, assessment methods, and clinical trial results.
- Exploration of practical management approaches for CIOP.
Main Results:
- Bisphosphonate therapy is effective for both prevention and treatment of CIOP.
- Data strongly support bisphosphonates over other agents for CIOP.
- Alternative therapies include hormone replacement, calcitonin, fluoride, or anabolic hormones for refractory cases.
- Calcium is an adjunctive therapy, not a primary treatment.
Conclusions:
- Bisphosphonates are the preferred agents for treating and preventing CIOP.
- Effective therapies exist despite incomplete understanding of CIOP mechanisms.
- Clinicians should consider bisphosphonates as first-line treatment for CIOP.
Related Concept Videos
01:40Bone Remodeling
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
01:31Osteoclasts in Bone Remodeling
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
01:29Bone Disorders
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
01:26COPD: Management Using Bronchodilators and Corticosteroids
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
01:21Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2 (COX-2),...
01:29Inflammatory Bowel Disease IV: Pharmacological Management
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...