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Impaired antiviral response and alpha/beta interferon induction in mice lacking beta interferon
R Deonarain1, A Alcamí, M Alexiou
1MRC Clinical Science Centre, Imperial College School of Medicine, Hammersmith Hospital, London W12 ONN, United Kingdom.
Journal of Virology
|March 9, 2000
Abstract:
We have generated mice lacking the gene for beta interferon and report that they are highly susceptible to vaccinia virus infection. Furthermore, in cultured embryo fibroblasts, viral induction of alpha interferon and of 2-5A synthetase genes is impaired. We also show that beta interferon does not prime its own expression.